This blog was revised and updated on February 11, 2025.
Data entry in laboratories was previously performed using physical notebooks. Not only was this tedious, but it also resulted in errors and inefficiency in operations. With the advent of Electronic Lab Notebook software, traditional notebooks became obsolete. While this led to improved efficiency and collaboration, a wide variety of ELNs started appearing on the market, making it difficult for labs to find the right solution. If you are in a similar situation, here’s a comprehensive guide to the different types of electronic lab notebooks available.
- Digital Solutions for Modern Laboratories
- What are the Different Types of Electronic Lab Notebooks?
- Informatics Solution Deployment Options
- Features
- How to choose the right software
- Discover Sapio
Use the links above to skip ahead to the questions you’re most interested in.
Or watch this short video to learn more about choosing the best lab notebook for drug research:
Digital Solutions for Modern Laboratories
Electronic Lab Notebooks are digital replacements for traditional paper records, designed to help researchers log, organize, and share their work with ease. Because every lab operates differently, a range of notebook types exists, each tailored to specific scientific needs and workflows. Read more in our full article: What is an Electronic Lab Notebook
What are the Different Types of Electronic Lab Notebooks?
Electronic Lab Notebooks come in many forms, each designed to meet specific research needs, workflows, and regulatory requirements. From solo researchers using lightweight tools to large organizations with integrated data ecosystems, they can be tailored to suit virtually any scientific context.
The table below outlines key categories of ELNs, highlighting their features, typical use cases, and unique advantages. It’s important to note that these categories are not mutually exclusive; many ELN solutions combine features from several of them. For example, a platform might be both science-aware and standard-compliant, or offer specialized biotech tools within an enterprise-grade system.
| Category | Key Features | Common Use Cases |
| Point Product | Basic tools for individuals or small teams; support basic data logging and collaboration. | Independent researchers, academic projects. |
| Enterprise-class | Scalable platforms with secure collaboration and integration across departments. | Pharma R&D, enterprise-level laboratories. |
| Specialized | Built for specific disciplines such as chemistry, biology, or clinical studies. | Regulated industries, targeted scientific domains. |
| Biotechnology/ Biologics | Templates for molecular biology, protein work, and bioinformatics. | Biotech research, antibody discovery, process optimization. |
| Solution-specific | Pre-built workflows for specific solution areas like gene therapy, NGS sequencing, etc. | Cell & gene therapy labs, bioanalytical research. |
| Chemistry | Features like stoichiometry calculators, reaction schematics, and inventory tools. | Synthetic route planning, SAR, compound screening. |
| Histopathology | Manage digital slides and annotated pathology reports with imaging system links. | Oncology research, diagnostic histopathology. |
| Science-aware | Include native data analysis and visualization tools within the ELN environment. | Data-heavy life sciences or physical sciences labs. |
| Standard-compliant | Support regulatory requirements such as GxP, CLIA, ISPE GAMP 5, SOC 2. | Clinical research, QA/QC teams, audit-ready labs. |
| Unified ELN with LIMS | Merges ELN and LIMS capabilities for full sample and workflow management. | Labs needing traceability, automation, and centralized systems. |
Informatics Solution Deployment Options
When selecting an Electronic Lab Notebook or a broader laboratory informatics system, one of the first considerations is how the solution will be deployed. Deployment models determine not only how software is accessed and maintained but also how data is stored, shared, and secured.
Laboratories may choose between on-premises, cloud-based, or hybrid models depending on their IT infrastructure, compliance requirements, and collaboration needs. Additionally, organizations must decide whether to implement standalone systems, integrated platforms, or industry-specific solutions that cater to specialized workflows.
The table below outlines the most common types of informatics solutions, with a focus on their deployment characteristics and integration capabilities. Keep in mind that these options are not always mutually exclusive; a lab informatics solution may incorporate elements from more than one deployment type.
| Solution Type | Description |
| On-premises Solutions | Installed and maintained locally, offering greater control over data and customization. Commonly includes Standalone ELNs that function without internet access. |
| Cloud-based Solutions | Provide remote access, scalability, and reduced IT burden. Suitable for cloud-based ELNs hosted on external servers. |
| Hybrid Solutions | Merge local and cloud infrastructure for flexible, secure lab operations. Can support both on-premise and cloud components. |
| Industry-specific Solutions | Tailored for sector-specific workflows and compliance needs. Encompasses specialized ELNs for areas like pharma, biotech, or academic research. |
| Platform ELNs | Integrated as part of a configurable informatics suite, typically including LIMS and Scientific Data Management Systems (SDMS). |
| Integrated ELNs | Tightly embedded within broader LIMS environments to synchronize lab data and streamline workflows. |
Features
Electronic Lab Notebook software makes it easier for researchers and lab analysts to store information and record findings through various functions, safety features and collaboration tools.
Here’s a quick overview of the top features of an ELN:
Experiment tracking and version control
This helps researchers keep track of experiments. By maintaining a history of revisions, researchers can reduce the risk of data loss and errors.
Data analysis and visualization tools
Most ELNs have in-built tools for data analysis and visualization. It eliminates the need to export data and improves decision-making.
Electronic data capture
It eliminates manual data entry, as data is collected directly from instruments and sensors, thereby improving efficiency and data accuracy.
Security and compliance features
Features such as role-based access controls and encryption help organizations ensure data integrity and confidentiality while complying with regulatory requirements.
Search and retrieval function
This helps researchers quickly find and retrieve past experiments, data and notes from large datasets.
Collaboration tools
Collaboration tools allow for real-time sharing and editing of data, notes and results.
How to choose the right ELN software
Given the vast array of Electronic Lab Notebooks available, choosing one right for your organization can be challenging. To make things easier, consider the following questions:
1. What features are important for maintaining efficiency in your lab operations?
2. Do you need a solution that can be scaled based on your needs?
3. Do you plan to integrate the ELN with other systems in your laboratory?
4. What is your budget for an ELN?
5. Does the ELN system have robust security measures and compliance functionalities?
Your answers to these questions will help you narrow down the vast amount of ELNs available in the market.
Discover Sapio ELN
ELNs are widely known for their benefits, including increased efficiency, collaboration and compliance. However, depending on the type of ELN software, their specific features and functionalities can vary.
When choosing Electronic Lab Notebook software, carefully analyze your laboratory’s requirements and involve your entire team to gain in-depth insights into which ELN would be an ideal fit.
Sapio Sciences offers a comprehensive electronic laboratory notebook solution designed to meet the diverse needs of modern laboratories. The Sapio ELN stands out with its robust features and seamless integration capabilities. Key aspects of Sapio ELN software include:
- No/low-code Configurable: Define your experiments, your way—no code needed.
- Lab Informatics Platform: An ELN, that is seamlessly part of a larger, flexible lab capability including a LIMS and Scientific Data Management solution.
- User-friendly Interface: Intuitive design that simplifies data entry and retrieval.
- Advanced Security: Top-tier security measures to protect sensitive research data.
- Integration with Sapio LIMS: Seamless integration with Sapio’s Laboratory Information Management System, enhancing overall lab efficiency.
- Customization: Highly customizable to fit the unique workflows of different research environments.
- Pricing: visit Sapio’s ELN pricing page.
Frequently Asked Questions
Q: What makes Sapio ELN different from other ELNs?
A: Sapio ELN is not integrated with Sapio LIMS but is actually part of the same lab platform, providing one user experience, one point to access data, one place to configure workflow and experiments, and one place to collaborate and analyze data. A comprehensive lab informatics platform for laboratory information and document management. Its advanced security features and user-friendly interface also set it apart.
Q: Can Sapio ELN be customized for specific research needs?
A: Yes, Sapio ELN is highly customizable, allowing it to adapt to the specific workflows and requirements of different research experiments and environments.
Q: Is Sapio ELN suitable for both small and large laboratories?
A: Yes, Sapio ELN is scalable and can be tailored to meet the needs of both small and large laboratories.
Useful Resources
1. Nature’s Guide on Picking an ELN:
This comprehensive guide from Nature discusses various factors to consider when selecting an ELN, such as costs, legal issues, stability, and software integration. It also provides practical advice on evaluating different ELN options and understanding their benefits in a research setting. This resource is particularly useful for understanding how to choose the right ELN for specific needs and environments.
[Read more on Nature](https://www.nature.com/articles/d41586-018-05895-3).
2. NIH Library’s Overview of ELNs:
The NIH Library offers a detailed overview of ELNs, including their advantages over traditional paper notebooks. It covers aspects like data entry, transparency, reproducibility, workflow development, version control, and rights management. This resource is helpful for those looking to understand the fundamental benefits and functionalities of ELNs in a research environment.
[Explore the NIH Library guide](https://www.nihlibrary.nih.gov/resources/subject-guides/electronic-lab-notebooks).
3. Harvard University’s Data Management Guide:
Harvard University provides an in-depth look at the use of electronic lab notebooks in research, emphasizing good data management practices, security, and collaboration. This guide explains how ELNs can facilitate data management, support auditing, and integrate with other research tools. It is an excellent resource for researchers seeking to implement effective data management strategies using ELNs.
[Check out Harvard’s data management guide](https://datamanagement.hms.harvard.edu/electronic-lab-notebooks).
