Sapio's Exemplar Software Achieves GeneChip compatible™ Status with Affymetrix' GeneChip® Microarray Platform

York, PA., September 18, 2005 – Sapio Sciences today announced that its Exemplar software application has achieved GeneChip-compatible™ status with the Affymetrix Inc. (Nasdaq: AFFX) GeneChip® microarray platform and that it has agreed to participate in the Affymetrix GeneChip-compatible™ Applications Program, which provides customers with a broad spectrum of software solutions for biomedical research and development. As a GeneChip-compatible™ software provider, Sapio is committed to seamlessly integrating its Exemplar Suite with the Affymetrix GeneChip platform. Sapio's Exemplar Analysis Suite, when combined with data generated from Affymetrix' GeneChip Mapping 10K, 100K and 500k Arrays, provides a powerful platform for performing whole genome association studies.

Exemplar provides multiple methods for analyzing genetic data including advanced machine learning methods as well as traditional statistical methods. Furthermore, Exemplar's built-in, research pipeline includes an extensive genomics database and unmatched integrated graphics for viewing the results of multiple analyses in one intuitive view. This enables researchers to easily identify where various analysis agree and disagree in their conclusions. Exemplars Integrated Approach to Analysis""Affymetrix GeneChip technology is the leading genotyping platform utilized by our customers. Affymetrix' rapid ramp up in density of coverage has enabled researchers to undertake genetic studies that were never before possible.", said Sapio CEO Kevin Cramer. "We have worked hard to deliver painless integration with these new technology platforms so our customers can focus on research, and not data input/formatting issues. We have also focused intensely on performance. As a result, Exemplar can easily handle the GeneChip Mapping 100KSet, and readily scales to handle the 500K Set."

"Affymetrix is dedicated to providing our customers with advanced solutions for applying genetic variation data in next-generation clinical studies.," said Steve Lincoln, vice president of Informatics at Affymetrix. "We are pleased to be working with innovative software companies, such as Sapio Sciences, in developing tools for this new market ."

About Sapio Sciences LLC
Sapio Sciences is a leading provider of bioinformatics software, enabling scientists to get biologically significant information from their sequence, gene and protein array experiments. Sapio continues to break new ground by combining ease of use, powerful and intuitive graphics with leading edge analytics. Sapio, with its extensive background in biological data analysis, also offers data analytics consulting for companies that want to outsource this function. In addition to working closely with Affymetrix, Sapio has formed partnerships with Illumina, Expression Analysis and Genome Explorations. Part of Sapio's mission is to support discovery research for human, animal, and plant afflictions. To fulfill this mission, Sapio is committed to creating world class, innovative solutions to aid life science researchers, and to donating a percentage of profits directly to research centers focused on identifying disease causes and cures. About the Affymetrix Developers Network (ADN) Through one of the largest third-party software developer communities within the life science industry, Affymetrix works with ADN participants to provide a broad spectrum of solutions for leveraging gene expression and genetic variation analysis in both biomedical research and development. Membership in ADN is free of charge for both commercial and academic software developers. For more information on the ADN program please visit www.affymetrix.com/genechip/developer. Visit the GeneChipcompatible Software Solutions Catalog at www.affymetrix.com/genechip/compatible.

About Affymetrix
Affymetrix scientists invented the world's first microarray in 1989 and began selling the first commercial microarray in 1994. Since then, Affymetrix GeneChip® technology has become the industry standard in molecular biology research. Affymetrix technology is used by the world's top pharmaceutical, diagnostic and biotechnology companies as well as leading academic, government and not-for-profit research institutes. More than 1,200 systems have been shipped around the world and more than 3,000 peer-reviewed papers have been published using the technology. Affymetrix' patented photolithographic manufacturing process provides the most information capacity available today on a microarray, enabling researchers to use a whole-genome approach to analyze the relationship between genetics and health. Headquartered in Santa Clara, Calif., Affymetrix has subsidiaries in Europe and Asia in addition to manufacturing facilities in Sacramento, Calif. and Bedford, Mass. The company has about 900 employees worldwide. For more information about Affymetrix, please visit the company's website at www.Affymetrix.com

For Further Information: Kevin Cramer Sapio Sciences LLc Tel: (717) 870-7928 Email: KCramer@sapiosciences.com